Table 4 Hematological parameters on post-injection effects at day 8 after seven doses (1, 5, and 10 mg/kg/day of AmB).

From: Biomimetically engineered Amphotericin B nano-aggregates circumvent toxicity constraints and treat systemic fungal infection in experimental animals

Parametersa

Dose (mg/kg/day)

Fungizone

AmBisome

AmB-NA3

AmB-NA5

Controlc

RBCb (×106/mL)

1

4.03 ± 0.4*

7.38 ± 1.8

7.45 ± 0.9

7.31 ± 1.3

7.47 ± 0.2

5

—

6.58 ± 0.7

7.01 ± 1.1

7.06 ± 1.6

10

—

4.41 ± 1.7

7.00 ± 0.6

6.90 ± 0.2

WBCsb (×103/μL)

1

4.17 ± 0.6*

6.20 ± 0.8

6.20 ± 1.5

6.40 ± 2.2

6.7 ± 0.4

5

—

6.00 ± 0.6

6.10 ± 0.4

6.20 ± 0.1

10

—

5.7 ± 0.9

5.80 ± 0.8

6.00 ± 1.2

Platelet (×103/μL)

1

155 ± 21*

460 ± 24

400 ± 35

442 ± 45

507 ± 24

5

—

410 ± 11

305 ± 16

398 ± 23

10

—

342 ± 32*

220 ± 22*

312 ± 12*

Hematocrit (%)

1

24.4 ± 2.9*

40.3 ± 0.5

41.6 ± 1.2

44.6 ± 2.1

46.2 ± 2.4

5

—

35.5 ± 2.0

41.0 ± 0.6

43.2 ± 2.8

10

—

36.5 ± 2.8

39.1 ± 2.9

42.0 ± 1.2

Hemoglobin (g/dL)

1

11.5 ± 1.1*

16.4 ± 0.9

16.9 ± 1.2

17.1 ± 0.4

17.2 ± 1.2

5

—

16.0 ± 0.3

16.5 ± 0.7

16.8 ± 0.9

10

—

15.3 ± 2.2

16.2 ± 1.1

16.5 ± 1.4

  1. The commercial formulation of Amphotericin B, Fungizone was given at dose of 1 mg/kg for 7 days.
  2. aAll parameters were expressed as mean values ± SD.
  3. bRBC, red blood cells; WBC, white blood cells.
  4. cControl groups received only PBS.
  5. *Significant at P < 0.05, Students t test.
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