Table 4 Correlation between mRNA level of PD-L1 and variable clinicopathologic parameters in 39 HER2-positive breast cancers with fresh tissue.
mRNA level of PD-L1 | p-value | ||
|---|---|---|---|
Low (number (%))* | High (number (%))* | ||
Age, mean ± SD ** | 55.65 ± 10.14 years | 55.00 ± 10.85 years | 0.849 |
Size, mean ± SD ** | 3.98 ± 2.09 cm | 4.57 ± 3.16 cm | 0.488 |
Side | 0.571 | ||
Right | 15 (65.2) | 9 (56.3) | |
Left | 8 (34.8) | 7 (43.8) | |
Histologic grade | 1.000 | ||
Grade 1, 2 | 8 (34.8) | 6 (37.5) | |
Grade 3 | 15 (65.2) | 10 (62.5) | |
Nuclear grade | 0.432 | ||
Grade 1, 2 | 6 (26.1) | 2 (12.5) | |
Grade 3 | 17 (73.9) | 14 (87.5) | |
Necrosis | 1.000 | ||
Absent | 6 (26.1) | 4 (25.0) | |
Present | 17 (73.9) | 12 (75.0) | |
Lymphovascular invasion | 0.743 | ||
Absent | 11 (47.8) | 6 (37.5) | |
Present | 12 (52.2) | 10 (62.5) | |
Lymph node metastasis | 0.291 | ||
Absent | 9 (39.1) | 3 (18.8) | |
Present | 14 (60.9) | 13 (81.3) | |
Stage | 0.112 | ||
Early (stage I, II) | 15 (65.2) | 6 (37.5) | |
Advanced (stage III, IV) | 8 (34.8) | 10 (62.5) | |
HR expression | 0.192 | ||
Positive | 13 (56.5) | 5 (31.3) | |
Negative | 10 (43.5) | 11 (68.8) | |
TILs level*** | 0.001 | ||
≤10% | 11 (47.8) | 1 (6.3) | |
20–60% | 12 (52.2) | 10 (62.5) | |
60% | 0 (0.0) | 5 (31.3) | |
TLSs around DCIS | 0.264 | ||
Low | 19 (82.6) | 10 (62.5) | |
High | 4 (17.4) | 6 (37.5) | |
TLSs around invasive component | 0.471 | ||
Low | 18 (78.3) | 10 (62.5) | |
High | 5 (21.7) | 6 (37.5) | |
