Figure 5
From: Sclerostin induced tumor growth, bone metastasis and osteolysis in breast cancer
Analyses of tumor characteristics and serum of xenografted mice. (A) Representative H&E staining and immunohistochemistry for sclerostin (100 × magnification) in tumor sections obtained from different groups. (B) Quantification of osteocalcin (OCN), (C) osteoprotegerin (OPG), and (D) sclerostin in serum of mice from different groups by ELISA. NC, non-treated control group; PBS, PBS-treated group; Scl-Ab, sclerostin antibody-treated group (1 μg antibody in 20 μl PBS). Each bar represents mean ± SEM. **P < 0.01, NS, non-significant.
