Table 1 Ki values against cathepsin X and the mechanism of inhibition.

From: Identification and characterization of the novel reversible and selective cathepsin X inhibitors

Compound

Ki (μM)

 

1*

38.40 ± 0.20

 

2*

29.20 ± 2.44

 

3*

259.74 ± 31.87

 

4*

230.21 ± 2.90

 

5*

135.90

 

Compound

Ki (μM)

Inhibition mechanism

12

5.88 ± 0.21

competitive

14

5.41 ± 0.19

competitive

17

7.35 ± 0.28

competitive

20

8.78 ± 0.39

competitive

22

2.45 ± 0.05

competitive

  1. *Ki values determined with SigmaPlot at 3 different substrate concentrations.
  2. Values are averages of at least two independent experiments, each performed in duplicate.
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