Figure 7
Insomnia-like Behaviors in Rogdi Mutants Are Sensitized to Select Anti-epileptic Drugs. Oral administration of anti-epileptic drugs showed differential effects on short sleep phenotypes in Rogdi mutants. Sleep behaviors in individual flies were analyzed similarly to the data presented in Fig. 1. Gray and orange bars indicate wild-type (w 1118) and Rogdi del mutant backgrounds, respectively. Data represent average ± SEM (n = 21–97). Two-way ANOVA detected significant interaction of Rogdi mutation with valproate and CBZ on sleep amount (F[1,185] = 17.73, P < 0.0001 for valproate; F[1,114] = 24.88, P < 0.0001 for CBZ) and sleep latency (F[1,185] = 3.892, P = 0.0500 for valproate; F[1,114] = 4.482, P = 0.0364 for CBZ). No significant interactions were observed between Rogdi mutation and gabapentin. n.s., not significant, *P < 0.05, ***P < 0.001 to no-drug controls in the same genetic backgrounds as determined by Tukey post hoc test.
