Figure 1 | Scientific Reports

Figure 1

From: Preserved immune functionality and high CMV-specific T-cell responses in HIV-infected individuals with poor CD4+ T-cell immune recovery

Figure 1

Phenotypic and functional changes induced by CMV infection. (A) CD4+ and CD8+ T-cell differentiation profile in HIV-uninfected CMV-seropositive and -seronegative individuals. The differential expression of CD45RA, CCR7 and CD27 by CD4+ and CD8+ T-cells was analyzed by boolean gating. Pie charts illustrate relative proportions of each of the different subsets in CMV-seropositive and CMV-seronegative. (B) CD4+ and CD8+ T-cell responses to PMA/ionomycin stimulation in HIV-uninfected individuals stratified by CMV serostatus. Polyfunctional profiles of CD4+ and CD8+ T-cells responding to PMA/ionomycin are showed. Detail of the 3-function combinations (IFN-γ, IL-2 and TNF-α) of CD4+ and CD8+ T-cells responding to PMA/ionomycin is depicted on the bottom of the figure. Statistical comparisons of the profiles were performed by partial permutation tests, using Spice software (*p < 0.05, **p < 0.01). HIV−: HIV-uninfected individuals; CMV−: CMV-seronegative individuals; CMV+: CMV-seropositive individuals.

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