Table 2 Characteristics of CMV+ participants.

From: Preserved immune functionality and high CMV-specific T-cell responses in HIV-infected individuals with poor CD4+ T-cell immune recovery

 

HIV+ Subgroups

CMV+ Uninfected controls (n = 13)

CMV+ HIV+-Infected ART-Treated (n = 36)

p-value1

CMV+ Immuno- concordant (n = 21)

CMV+ Immuno- discordant (n = 15)

p-value2

Gender (male); n (%)

7 (54)

30 (86)

0.048

17 (81)

14 (93.3)

0.38

Age (years); Median [IQR]

46 [41–54]

49 [48–54]

0.078

49 [48–54]

50 [48–54]

0.63

Absolute CD4+ T-cell count (cells/µL); Median [IQR]

643 [542–823]

451 [257–963]

0.38

888 [661–1225]

251 [166–351]

<0.0001

Absolute CD8+ T-cell count (cells/µL); Median [IQR]

344 [298–366]

668 [409–906]

<0.0001

753 [618–1333]

398 [333–654]

0.0014

CD4+ Nadir (cells/µL); Median [IQR]

 

116 [51–188]

 

163 [65–282]

61 [20–134]

0.01

Time since HIV diagnosis (years); Median [IQR]

 

22 [18–29]

 

22 [18–28]

26 [19–22]

0.46

Time on ART (years); Median [IQR]

 

18 [15–24]

 

17 [15–20]

20 [12–24]

0.9

HCV co-infection; n (%)

 

14 [39]

 

8 (38)

6 (40)

1

  1. 1Comparison of CMV+HIV-infected ART-treated and CMV+ uninfected individuals (Mann-Withney U or Fisher exact test). 2Comparison of CMV+ immunoconcordant and CMV+ immunodiscordant HIV-infected ART-treated individuals (Mann-Withney U or Fisher exact test).