Table 1 cAMP enhances the repair of cisplatin-induced DNA damage.

Primary human melanocytes (PHM), HEK293-MC1R-WT or HEK293-MC1R-R151C cells were pre-treated with either MSH (100 nM), MSH (100 nM) + ASIP (100 nM) or HBD3 (100 nM) or forskolin (10 µM), forskolin (10 µM) + ASIP (100 nM) or forskolin (10 µM) + HBD3 (100 nM), 30 minutes before cisplatin (100 µM) or mock treatment for 1 hr. Following which, the repair of intra-strand DNA damage was monitored using an anti-pt-GpG antibody. Repair efficiencies are expressed as time taken in hours to repair 50% of initial damage and expressed as mean ± SEM. Values not sharing a common letter were significantly different for each treatment (per cell type) as determined by one-way ANOVA; p ≤ 0.05. Data are expressed as mean ± SEM from three independent experiments.

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