Figure 5
From: Therapeutic Effectiveness of Anti-RAGE Antibody Administration in a Rat Model of Crush Injury
Immunofluorescent RAGE expression in the lung alveoli following crush injury. (A) The red signal indicates the expression of RAGE, and the blue signal indicates the location of the nucleus. In the lung, markedly upregulated RAGE in the RAGE-Ctrl group was suppressed by the administration of anti-RAGE antibody in the RAGE-Tx group at both times compared with that in the RAGE-Ctrl group. Bars represent 100 µm. Original magnification ×200. (B) Results of statistical analysis of the relative intensity of RAGE. Relative intensity was calculated by averaging fluorescent immunostaining in 10 randomly selected slide fields in the lung. All data are expressed as mean ± SD. RAGE-Sh group (n = 3), RAGE-Ctrl group (n = 4), RAGE-Tx group (n = 4). **P < 0.01.
