Table 1 Affinities of AngII and Ang-(1-7) for the AT1 receptor from competition binding assays, and functional data presented as potencies (pEC50) and efficacies (Emax) in promoting G protein- dependent signaling pathways.

From: Ang-(1-7) is an endogenous β-arrestin-biased agonist of the AT1 receptor with protective action in cardiac hypertrophy

 

Binding

Gq activation

Ca2+ mobilization

Gi3 activation

pKi

pEC50

Emax (%)

pEC50

Emax (%)

pEC50

Emax (%)

AngII

8.81 ± 0.25

8.39 ± 0.10

100

8.75 ± 0.14

100

8.11 ± 0.25

100

Ang-(1-7)

6.66 ± 0.14

N.D.

12.8

N.D.

24.8

N.D.

N.D.

  1. N.D.: Values could not be determined. EC50 values are presented as mean ± SEM of at least three independent experiments. Emax values for Ang-(1-7) are shown as a percentage of the maximum values obtained for AngII.
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