Figure 5

Alternative synthetic method for synthesis of compound 10. Reagents and conditions: (a) Pd2(dba)3, XPhos, NaOtBu, anhydrous toluene, rt to 100 °C, 92%; (b) TFA, Et2O, 0 °C to rt, 8 h, 65%.

Alternative synthetic method for synthesis of compound 10. Reagents and conditions: (a) Pd2(dba)3, XPhos, NaOtBu, anhydrous toluene, rt to 100 °C, 92%; (b) TFA, Et2O, 0 °C to rt, 8 h, 65%.