Table 2 Plausible target profiling of drug scaffold 1 resulting from 2D-similarity search, SEA.
No. | #Lig | Reference Name | E-value | MaxT | CTD Gene Symbol | Diseases | Molecules |
|---|---|---|---|---|---|---|---|
1 | 18 | Quinone reductase 1 (human) | 0.232 | 0.30 | NQO1 | Cytoprotection; cancer; Alzheimer’s disease; tardive dyskinesia |
|
2 | 139 | Epoxide hydratase (mouse) | 0.939 | 0.35 | EPHX | Acute inflammation; MI(Cardiac); Cancer; depression |
|
3 | 24 | Calpain 2 (pig) | 1.25 | 0.31 | CAPN2 | Alzheimer’s disease |
|
4 | 30 | Calpain 2 | 3.98 | 0.31 | CAPN2 | Alzheimer’s disease |
|
5 | 30 | Quinone reductase 1 | 4.18 | 0.30 | NQO1 | Cytoprotection; cancer; Alzheimer’s disease; tardive dyskinesia |
|
6 | 118 | Epoxide hydratase | 8.31 | 0.35 | EPHX | Acute inflammation; MI(Cardiac); Cancer; depression |
|
