Table 3 Inhibitory effects of compounds (4a–f, 5, and 10) on LPS-induced NO production in BV-2 cells.

From: Pharmacological use of a novel scaffold, anomeric N,N-diarylamino tetrahydropyran: molecular similarity search, chemocentric target profiling, and experimental evidence

Entry

Compound

Structure

Yield (%)

IC50(µg/mL)a

 

Entry

Compound

Structure

Yield (%)

IC50(µg/mL)a

1

4a

70

75.66

 

6

4f

78

20.21

2

4b

89

>500

 

7

5

31

>500

3

4c

45

162.49

 

8

10

65

12.57

4

4d

80

>500

 

9

6-Shogaolb

-

5.59

5

4e

99

>500

      
  1. aData are presented as means ± of three independent experiments. bPositive control.
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