Table 2 Top 20 DEGs identified in the meta-analysis of DLGG vs. NG and A vs. OD tissues. The DEGs were ranked according to the combined effect size. Abbreviations: ES, effect size; DLGG, diffused low-grade glioma; NG, non-glioma NG; A, astrocytoma; OD, oligodendroglioma.
Entrez ID | Gene symbol | Gene name | Combined ES | Adjusted p-value |
|---|---|---|---|---|
Top 10 upregulated genes in DLGG vs. NG | ||||
6678 | SPARC | Secreted protein acidic and cysteine rich | 2.8727 | 0 |
10797 | MTHFD2 | Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 2.8634 | 0 |
5803 | PTPRZ1 | Protein tyrosine phosphatase, receptor type Z1 | 2.7797 | 1.26E-10 |
6659 | SOX4 | SRY-box 4 | 2.6366 | 0 |
9459 | ARHGEF6 | Rac/Cdc42 guanine nucleotide exchange factor 6 | 2.4971 | 0 |
5375 | PMP2 | Peripheral myelin protein 2 | 2.4946 | 0 |
6938 | TCF12 | Transcription factor 12 | 2.4753 | 0 |
6175 | RPLP0 | Ribosomal protein lateral stalk subunit P0 | 2.4696 | 0 |
7079 | TIMP4 | TIMP metallopeptidase inhibitor 4 | 2.4588 | 0 |
7078 | TIMP3 | TIMP metallopeptidase inhibitor 3 | 2.3411 | 0 |
Top 10 downregulated genes in DLGG vs. NG | ||||
5950 | RBP4 | Retinol-binding protein 4 | −2⊡7344 | 6.24E-15 |
887 | CCKBR | Cholecystokinin B receptor | −2⊡6242 | 6.24E-15 |
6804 | STX1A | Syntaxin 1A | −2⊡5435 | 0 |
23531 | MMD | Monocyte to macrophage differentiation associated | −2.5336 | 0 |
7781 | SLC30A3 | Solute carrier family 30 member 3 | −2.5278 | 7.92E-09 |
1428 | CRYM | Crystallin mu | −2.4535 | 0 |
1020 | CDK5 | Cyclin-dependent kinase 5 | −2.4533 | 0 |
3761 | KCNJ4 | Potassium voltage-gated channel subfamily J member 4 | −2.4439 | 0 |
2555 | GABRA2 | Gamma-aminobutyric acid type A receptor alpha2 subunit | −2.4082 | 0 |
529 | ATP6V1E1 | ATPase H+ transporting V1 subunit E1 | −2.4026 | 0 |
Top 10 Upregulated Genes in A vs. OD | ||||
51411 | BIN2 | Bridging integrator 2 | 1.6907 | 0.0000223 |
6916 | TBXAS1 | Thromboxane A synthase 1 | 1.6221 | 0.0000863 |
338773 | TMEM119 | Transmembrane protein 119 | 1.6106 | 0.000045 |
7462 | LAT2 | Linker for activation of T-cells family member 2 | 1.5738 | 0.0000291 |
81704 | DOCK8 | Dedicator of cytokinesis 8 | 1.5245 | 0.0000641 |
54518 | APBB1IP | Amyloid beta precursor protein binding family B member 1 interacting protein | 1.4871 | 0.0000329 |
5272 | SERPINB9 | Serpin family B member 9 | 1.4734 | 0.000000143 |
23533 | PIK3R5 | Phosphoinositide-3-kinase regulatory subunit 5 | 1.4619 | 0.00000757 |
54440 | SASH3 | SAM and SH3 domain containing 3 | 1.4526 | 0.00000121 |
112616 | CMTM7 | CKLF-like MARVEL transmembrane domain containing 7 | 1.4252 | 0.0000214 |
Top 10 downregulated genes in A vs. OD | ||||
55140 | ELP3 | Elongator acetyltransferase complex subunit 3 | −1.4435 | 0.0000694 |
3313 | HSPA9 | Heat shock protein family A (Hsp70) member 9 | −1.318 | 8.73E-08 |
9026 | HIP1R | Huntingtin interacting protein 1 related | −1.3054 | 2.84E-09 |
23219 | FBXO28 | F-box protein 28 | −1.2516 | 0.0000275 |
84894 | LINGO1 | Leucine rich repeat and Ig domain containing 1 | −1.2256 | 0.0000642 |
440026 | TMEM41B | Transmembrane protein 41B | −1.2254 | 8.18E-11 |
79608 | RIC3 | RIC3 acetylcholine receptor chaperone | −1.2223 | 8.18E-11 |
51340 | CRNKL1 | Crooked neck pre-mRNA splicing factor 1 | −1.2067 | 0.0000443 |
140767 | NRSN1 | Neurensin 1 | −1.1524 | 0.0000705 |
8539 | API5 | Apoptosis inhibitor 5 | −1.1432 | 1.12E-09 |
