Figure 3
Gene Ontology analysis of differentially methylated promoters in responders and non-responders. (A–B) Gene ontology analysis using PANTHER with the DNA methylation data at 3 weeks, 4 months and 8 months describing the overrepresented biological pathways on the Y- axis and log 10 adjusted p values (<0.01) on the X- axis. Immune function-related pathways are represented as red bars. No enrichments were found for the non-responders at 3 weeks’ time point. (C) Venn diagram showing the overlap of differentially methylated promoters (represented as absolute numbers) at 3 weeks (pink), 4 months (blue) and 8 months (green). Numbers within brackets show the corresponding percentages of total hypo or hyper-methylated promoters. (D) gene ontology analysis of the promoters overlapping between the 3 weeks’ and 4 months’ time point in the responders. No corresponding enrichments were found for the non-responders. Promoters with a loss of methylation are shown in the white bubbles and those with a gain of methylation are shown in the black bubbles. Abbreviations: pr = process, reg = regulation.
