Figure 4
Global DNA methylation changes in NK cells from responders and non- responders (A) Volcano plot showing the DNA methylation pattern in NK cells at 3 weeks compared to before BCG. The red dots represent the promoters where the difference in methylation β values as compared to before BCG was greater than 5-fold. Red dots on left represent the promoters with a loss of methylation while those on right represent the promoters with a gain of methylation. (B) Gene ontology analysis of differentially methylated promoters in NK cells at three weeks. The graphs depict the overrepresented biological pathways on the Y- axis and log 10 adjusted p values (<0.01) on the X- axis.
