Figure 5 | Scientific Reports

Figure 5

From: Bumetanide treatment during early development rescues maternal separation-induced susceptibility to stress

Figure 5The alternative text for this image may have been generated using AI.

Systemic treatment with bumetanide during early development restored behavioral abnormalities in adolescent rats after maternal separation. (A) Experimental timeline of maternal separation, drug treatment, and behavioral tests. (B) Immobility time in the FST. (C) Sucrose preference in the SPT. (D) Percentage of entries into the open arms in the EPM. (E) Time spent in arms in the EPM. Time spent in the open arms is plotted as a percentage of the total observation time. (F) Total distance travelled in 5 min in the OFT. (G) Time spent in the central area in the OFT. (H) Latency to feed in the novelty-suppressed feeding test (NSFT). (I) Food consumption in the homecage over 5 min in the NSFT. n = 16–20 per group (8–10 females, 8–10 males). The data are expressed as mean ± SEM. *p < 0.05.

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