Figure 7 | Scientific Reports

Figure 7

From: Bumetanide treatment during early development rescues maternal separation-induced susceptibility to stress

Figure 7The alternative text for this image may have been generated using AI.

Systemic treatment with bumetanide during early development restored behavioral abnormalities in adult rats after maternal separation. (A) Experimental timeline of maternal separation, drug treatment, and forced swimming (FS) stress during adolescence and behavioral tests in adult rats. (B) Sucrose preference in the SPT. (C) Immobility time in the FST. (D) Percentage of entries into the open arms in the EPM. (E) Time spent in arms in the EPM. Time spent in the open arms is plotted as a percentage of the total observation time. (F) Total distance travelled in 5 min in the OFT. (G) Time spent in the central area in the OFT. (H) Serum osmolality of each group. The standard curve of osmolality test was shown in Fig S3. n = 12 per group (6 females, 6 males).The data are expressed as mean ± SEM. *p < 0.05.

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