Figure 7
From: Activation of miR-34a-5p/Sirt1/p66shc pathway contributes to doxorubicin-induced cardiotoxicity
Schematic diagram of the mechanism whereby miR-34a-5p exerts the pro-apoptotic effect in DOx-induced toxic cardiomyopathy. MiR-34a-5p is upregulated in Dox-induced H9c2 cells via NF-κB pathway. MiR-34a-5p enhances p66shc expression by targeting Sirt1, resulting in increases of Bax and the activated caspase-3, and a decrease of Bcl-2 (Bcl-2 is also a direct target of miR-34a-5p), and contributing to Dox-induced apoptosis of cardiomyocytes.
