Figure 1

Effects of ticagrelor on platelet aggregation and infarct volume 22 hours after reperfusion. (A) Experimental protocol for the measurement of platelet aggregation and infarct volume. (B) Adenosine diphosphate-induced platelet aggregation after administration of ticagrelor. Data are expressed as means ± standard errors of the mean (SEMs). N = 3 or 4 per group; **P < 0.01 vs. vehicle; Student’s t-test. (C) Representative images of triphenyltetrazolium chloride-stained coronal slices 22 hours after reperfusion. (D) Quantitative measurements of infarct volume 22 hours after reperfusion. Data are expressed as means ± SEMs. N = 10 to 12 per group; *P < 0.05 vs. vehicle; Student’s t-test.