Figure 2 | Scientific Reports

Figure 2

From: Differential Proteomics Identifies Reticulocalbin-3 as a Novel Negative Mediator of Collagen Production in Human Cardiac Fibroblasts

Figure 2

Protein interactome network for RCN proteins. Functional interactors of RCN-1 (A), RCN-2 (B), and RCN-3 (C) extracted from STRING tool. This database includes interactions from published literature describing experimentally studied interactions, as well as those from genome analysis using several well-established methods based on domain fusion, phylogenetic profiling and gene neighbourhood concepts. Accordingly, a confidence score for every protein–protein association is assigned to the network. A higher score is assigned when an association is supported by several types of evidence. To minimize false positives as well as false negatives, all interactions tagged as “low-confidence” (<0.150) in STRING database were eliminated from this study. Proteins are represented with nodes and the interactions with continuous lines represent direct interactions. Stronger associations are represented by thicker lines.

Back to article page