Figure 5
Impact of oil and CCl4 injections on liver portal tracts collagen fibrils expansion and remodeling after one-day oil injection (oil-D1), 8 weeks oil injection (Oil-W8) and 8 weeks CCl4 injection (W8-CCl4). (a) Collagen proportionate area (green bars) and ratio of peri-portal collagen area over luminal area (white bars). Note that for collagen proportionate area normalization relative to the mean area obtained for one-day oil injection was undertaken. (b) Collagen fibril angular disorder \({\theta }_{Tr}\) determined the sub-classification of the vessels in group 1 (red bars, \({\theta }_{Tr} > 0\)) and group 2 (yellow bars, \({\theta }_{Tr}=0\)). Note that for group 2 vessels, an arbitrary value of \({\theta }_{Tr}=0.5\) is plotted for clarity. (c) Experimental mean anisotropy parameter ρ exp after sub-classification of the vessels in group 1 (red bars, \({\theta }_{Tr}\ne 0\)) and group 2 (yellow bars, \({\theta }_{Tr}=0\)) based on \({\theta }_{Tr}\). (d) Percentage of group 1 (red bars) and group 2 (yellow bars) vessels as a function of the indicated experimental condition. The numbers (n) of vessels are 32, 101 and 105 for respectively Oil-D1 (3 animals), Oil-W8 (8 animals) and CCl4-injected (8 animals) mice. Note that the legend of the bars is located at the bottom of the figure. Note also that two (**) and three asterisks (***) have respectively the following significant meaning 0.001 < p < 0.01, p < 0.001 based on student t-test.
