Table 1 S. aureus isolate characteristics grouped by PR3-ANCA, MPO-ANCA and HC1.

From: Genetic loci of Staphylococcus aureus associated with anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides

 

PR3-ANCA isolates (n = 61)

MPO-ANCA isolates (n = 27)

HC isolates (n = 18)

No. of patients

32

27

10

No. of males (%)

22 (69)

11 (41)

4 (40)

Age at time of swab, mean ± SD

55 ± 13

60 ± 13

33.6 ± 11.8

Collection period

2006–2012

2010–2013

2007–2010

spa-types (%)

t002 (1.6)

t002 (3.7)

t002 (5.6)

 

t012 (14.8)

t012 (16.7)

t021 (1.6)

t021 (3.7)

t021 (11.1)

t064 (37.7)

t064 (3.7)

 

t091 (21.3)

t091 (22.2)

t091 (11.1)

t015 (1.6)

t026 (7.4)

t008 (5.6)

t072 (3.3)

t065 (3.7)

t024 (5.6)

t089 (3.3)

t126 (3.7)

t122 (11.1)

t224 (1.6)

t223 (7.4)

t209 (5.6)

t451 (1.6)

t362 (3.7)

t230 (5.6)

t539 (6.6)

t442 (3.7)

t359 (5.6)

t1246 (3.3)

t711 (3.7)

t2109 (11.1)

t1265 (1.6)

t888 (3.7)

t6076 (5.6)

t1361 (1.6)

t1168 (3.7)

 

t1508 (3.3)

t2849 (3.7)

 

t2658 (1.6)

t6365 (3.7)

 

t3092 (3.3)

t13788 (3.7)

 

t4584 (1.6)

  

t12249 (3.3)

  

CC* strain assignment (%)

CC5 (14.8)

CC5 (11.1)

CC5 (5.5)

CC7 (21.3)

CC7 (22.2)

CC7 (11.1)

CC8 (45.9)

CC8 (14.8)

CC8 (11.1)

CC22 (1.6)

CC22 (7.4)

CC22 (5.5)

CC30 (4.9)

CC30 (18.5)

CC30 (38.8)

CC45 (1.6)

CC45 (14.8)

CC45 (5.5)

CC1 (3.3)

CC12 (3.7)

CC9 (5.5)

CC25 (3.3)

CC361 (3.7)

CC20 (11.1)

CC97 (1.6)

CC101 (3.7)

CC97 (5.5)

None (1.6)

  

agr type (%)

I (75.4)

I (66.7)

I (50)

II (14.8)

II (14.8)

II (11.1)

III (8.2)

III (18.5)

III (38.9)

None (1.6)

  

No. of mecA-positive isolates

0

1

0

No. of tst-1-positive isolates

2

5

8

No. of PVL-positive isolates

0

0

0

  1. 1The 61 isolates from 32 PR3-ANCA-positive patients (denoted PR3-ANCA isolates) and 18 isolates from 10 HC (denoted HC isolates) have previously been described11,14,26. In addition, 27 nasal S. aureus isolates from 27 MPO-ANCA-positive patients (denoted MPO-ANCA isolates) visiting our outpatient clinic were collected. At first, all isolates were characterized by spa-typing27, revealing that among the MPO-ANCA isolates the spa-types t012, t064 and t091 were predominant, similar to the PR3-ANCA and HC collection (Table 1)10. *CC; clonal complexes.
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