Figure 2
From: The Regulatory Small RNA MarS Supports Virulence of Streptococcus pyogenes
Deletion of marS leads to a decreased survival of GAS M49 591 in human blood and greater susceptibility to phagocytosis. (A) Relative growth of ∆marS (dark grey) and ΔmarS::marS (light grey) in comparison to WT (black) in human blood, n = 12, and (B) in human plasma, n = 4. (C) Relative survival of ∆marS (dark grey) and ΔmarS::marS (light grey) in comparison to WT (black) after incubation for 30 min with human neutrophils, n = 5. (D) Relative abundance of associated ∆marS (dark grey) and ΔmarS::marS (light grey) bacteria in comparison to WT (black) after incubation with neutrophils n = 5. The Data are presented relative to WT (% WT, mean values ± standard deviation). Statistical significance was determined using the Wilcoxon signed-rank test. Differences between samples were expressed as “ns = not significant” (P ≥ 0.05), marginally significant (P < 0.05)*, and significant (P < 0.01)**.
