Table 2 Differentially expressed proteins in the proteomes of GAS M49 591 WT, ΔmarS and ΔmarS::marS. Detailed data are provided in Supplementary Data S1.

Immunogenic secreted protein

isp2

3.1

2.4

5.3

2.0

1.3

1.7

Collagen-like surface protein A

sclA

n.d.^a

6.6

16.2

n.d.

0.7

0.8

C5a peptidase

scpA

21.2^b

4.2

9.2

1.4^b

1.0

1.0

Antiphagocytic M protein

emm49

10.7

11.1

7.5^c

1.6

0.9

0.9

Fc-gamma receptor

Spy49_1672c

10.4

9.7

4.3

1.1

1.3

1.2

M protein trans-acting positive regulator

mga

117.2

62.5

45.2^c

2.2

1.2

1.1

Fibronectin-binding protein

sfbX49

28.4

11.2

21.3

2.0

0.9

3.1

Serum opacity factor

sof

6.5^b

3.7

9.5

3.1

1.1

1.6

Putative secreted protein

Spy49_0015

1.6^b

2.6

1.3

1.5

2.0

0.8

Thiol-activated cytolysin

slo

3.1

1.1

3.2

1.1

0.4

0.6

Uncharacterized protein

Spy49_0343

n.d.

17.8^b

8.6^b

n.d.

1.0^b

0.6^b

Uncharacterized protein

Spy49_0412

n.d.

n.d.

8.7

n.d.

n.d.

0.8

Collagen-like surface protein B

sclB

4.7

5.4

5.3

1.1

1.0

0.9

Spi SpeB protease inhibitor

Spy49_1689c

n.d.

n.d.

2.3

n.d.

n.d.

6.9

Cysteine proteinase SpeB

speB

n.d.

2.4

5.2

n.d.

13.8

4.7

Hyaluronan synthase

hasA

1.1

0.7

0.4

0.2

0.1

0.1

Putative UDP-glucose 6-dehydrogenase

hasB

1.2

1.5

1.2^b

0.1

0.3

0.5^b