Figure 4
From: An invertebrate infection model for evaluating anti-fungal agents against dermatophytosis
Therapeutic effects of terbinafine and itraconazole in silkworms infected with A. vanbreuseghemii TIMM2789 dermatophytes. Conidia of A. vanbreuseghemii TIMM2789 dermatophytes were cultured at 28 °C for 24 h. Cultured conidia (4 × 106) were injected into the silkworm hemolymph, followed by injection of 20 μg of terbinafine or 50 μg of itraconazole into hemolymph (i.h.: intra-hemolymph injection) or midgut (i.m.: intra-midgut injection). The silkworms were reared at 30 °C, and survival of the animals was monitored. n = 10/group.
