Figure 2
From: Kinetic constraints on self-assembly into closed supramolecular structures
Scaling behavior of viral capsid assembly properties and assembly efficiency. (a) Scaling of t max with m(0) as predicted by Eq. (11) for various viral systems with data shown as circles (BMV), squares (HPV) and hexagons (HBV). (b) The reaction order for nucleation, n c , is obtained from the scaling behavior of r max . The data are for HBV and HPV. Note that discontinuities in the experimental kinetic traces for HPV assembly are responsible for inaccuracies in determining r max for data at higher initial concentrations. (c) Balance between elongation and nucleation in the viral systems studied in this work. Green solid line corresponds to ε = 4.9 × 10−5, green dashed lines correspond to ε c (Eq. (14)) for the various viruses. BMV data denoted by circles, HPV by squares, HBV by hexagons and HBV assembly data obtained at 37 °C and pH 7.5 from50 (see Supplementary Information) by triangles. Blue data are from actin polymerization measurements in magnesium (stars) or in calcium (diamonds) from51. Viral images reproduced from23 with permission.
