Figure 3
From: SHH signaling directed by two oral epithelium-specific enhancers controls tooth and oral development
Motifs shared between MRCS1 and MFCS4. (a) Diagram of the upstream region of the mouse Shh locus. The two epithelial enhancers MFCS4 (blue) and MRCS1 (green) are located at 620–720 kb upstream of the Shh TSS. Comparison of mouse MRCS1 (b) and MFCS4 (c) in vertebrate taxa by Vista plots. A shaded region represents the core unit of the enhancer, which contains three shared motifs. The core sequences are shown at the bottom of (b). (d) Alignments of the three motifs in the MFCS4 and MRCS1 sequences, which were obtained from seven vertebrate species.
