Figure 1

Plenish induces less obesity and insulin resistance than conventional soybean oil, but similar levels of diabetes and hepatic steatosis. (a) Average weekly body weight of male C57BL/6 N mice on Vivarium chow (Viv) and 40 kcal% high fat diets: CO, coconut oil; SO + CO, conventional soybean oil-enriched; PL + CO, Plenish oil-enriched. Inset, average weight after 23 weeks on diet. N = 12 per group except for Viv (N = 23). *All diets are significantly different from each other, ^asignificantly greater than all others, ^bthan Viv and CO, ^cthan Viv. (b) Average weight of white adipose tissues. N = 11–12. ^aSignificantly greater than all others, ^bthan Viv and CO, ^cthan Viv. (c) Fasting blood glucose. (d) GTT area under the curve (AUC) of mice on diets for 22 weeks. N = 7–12. ^dSignificantly greater than CO. (e) ITT AUC of mice on diets for 20 weeks. N = 8-9. (c–e) See Fig. 6d for Viv values: CO is not significantly different from Viv. ITT AUC: SO + CO vs. Viv (P < 0.05). (f) Representative Oil Red O staining of livers from mice on the diets for 24 weeks. Scale bar is 100 microns. Each section is from one of 4-6 mice per group. (See Supplementary Fig. S2 for additional stains.) Data are presented as ± SEM (a–e).