Table 3 Combined genotype and allele frequencies of the MTHFR 3′-UTR polymorphisms for ischemic stroke patients and control subjects.
Genotypes | Controls freq. (n = 411) | Case freq. (n = 511) | AOR (95% CI) | P † | P ‡ |
|---|---|---|---|---|---|
MTHFR 2572/4869/5488/6685 genotype combination | |||||
CC/CC/CC/TT | 0.652 | 0.644 | 1.000 (reference) | ||
CC/CC/CC/TC | 0.029 | 0.002 | 0.095 (0.012–0.761) | 0.027 | 0.149 |
CC/CC/CT/TT | 0.000 | 0.002 | 0.393 (0.021–7.323) | 0.531 | 0.680 |
CA/CC/CC/TT | 0.022 | 0.065 | 2.922 (1.342–6.361) | 0.007 | 0.077 |
CA/CC/CC/TC | 0.141 | 0.145 | 1.106 (0.745–1.642) | 0.618 | 0.680 |
CA/CC/CT/TT | 0.024 | 0.010 | 0.475 (0.157–1.438) | 0.188 | 0.528 |
CA/CC/CT/TC | 0.010 | 0.002 | 0.309 (0.034–2.844) | 0.299 | 0.581 |
CA/CG/CT/TT | 0.085 | 0.092 | 1.218 (0.746–1.989) | 0.431 | 0.677 |
AA/CC/CC/TT | 0.005 | 0.002 | 0.524 (0.044–6.192) | 0.608 | 0.680 |
AA/CC/CC/CC | 0.005 | 0.014 | 3.004 (0.575–15.704) | 0.192 | 0.528 |
AA/CC/CT/TC | 0.005 | 0.002 | 0.628 (0.056–7.100) | 0.707 | 0.707 |
AA/CG/CT/TC | 0.007 | 0.002 | 0.295 (0.027–3.213) | 0.317 | 0.581 |
MTHFR 2572/4869/5488/6685 allele combination | |||||
C-C-C-T | 0.812 | 0.807 | 1.000 (reference) | ||
C-C-C-C | 0.016 | 0.001 | 0.062 (0.008–0.477) | 0.001 | 0.006 |
C-C-T-T | 0.001 | 0.001 | 0.809 (0.050–12.96) | 1.000 | 1.000 |
C-G-C-T | 0.000 | 0.002 | 4.043 (0.194–84.42) | 0.505 | 0.758 |
C-G-T-T | 0.001 | 0.000 | 0.270 (0.011–6.632) | 0.447 | 0.758 |
C-G-T-C | 0.001 | 0.000 | 0.270 (0.011–6.632) | 0.447 | 0.758 |
A-C-C-T | 0.016 | 0.035 | 2.239 (1.178–4.257) | 0.013 | 0.078 |
A-C-C-C | 0.081 | 0.088 | 1.086 (0.779–1.514) | 0.673 | 0.897 |
A-C-T-T | 0.016 | 0.014 | 0.871 (0.406–1.865) | 0.846 | 1.000 |
A-C-T-C | 0.005 | 0.001 | 0.202 (0.023–1.814) | 0.180 | 0.600 |
A-G-C-T | 0.000 | 0.003 | 5.660 (0.292–109.9) | 0.258 | 0.619 |
A-G-T-T | 0.047 | 0.048 | 1.016 (0.659–1.566) | 1.000 | 1.000 |
A-G-T-C | 0.003 | 0.000 | 0.162 (0.008–3.377) | 0.200 | 0.600 |
