Table 1 Hematologic parameters from mice with various treatment groups.

From: Synergistic effect of a drug loaded electrospun patch and systemic chemotherapy in pancreatic cancer xenograft

 

Unit

Sham patch

Gemcitabine IP

5-FU patch

5-FU patch + Gemcitabine IP

P value

POD 3

WBC

103/uL

4.85 ± 1.10

2.48 ± 0.25

2.95 ± 1.97

1.57 ± 0.52

0.029

   NEU

%

37.23 ± 3.45

25.48 ± 7.71

30.97 ± 3.02

17.23 ± 5.51

0.01

   LYMP

%

54.13 ± 6.16

69.18 ± 7.97

54.03 ± 14.07

68.33 ± 1.51

0.079

   MONO

%

2.23 ± 1.45

1.68 ± 0.94

0.53 ± 0.35

0.43 ± 0.21

0.088

RBC

106/uL

8.49 ± 0.05

8.93 ± 0.69

8.51 ± 0.33

8.07 ± 0.09

0.139

HGB

g/dL

12.77 ± 0.23

13.85 ± 1.01

13.00 ± 0.61

12.27 ± 0.12

0.062

HCT

%

40.37 ± 0.31

42.75 ± 1.63

39.97 ± 1.88

37.83 ± 0.45

0.006

Retic

%

4.29 ± 0.52

3.80 ± 0.40

1.32 ± 2.21

0.03 ± 0.02

0.002

PLT

103/uL

1128.67 ± 122.03

823.50 ± 64.20

714.00 ± 177.05

493.00 ± 83.54

0.001

AST

IU/L

55.43 ± 7.73

58.83 ± 13.89

60.63 ± 9.93

69.73 ± 12.76

0.506

ALT

IU/L

26.80 ± 5.37

24.85 ± 7.52

20.40 ± 3.17

17.53 ± 2.27

0.197

TP

g/dL

3.75 ± 0.08

3.79 ± 0.36

3.88 ± 0.24

3.68 ± 0.12

0.792

BUN

mg/dL

20.03 ± 1.29

20.68 ± 2.04

20.30 ± 2.21

22.20 ± 4.47

0.765

Cr

mg/dL

0.29 ± 0.03

0.31 ± 0.08

0.26 ± 0.06

0.26 ± 0.04

0.620

POD 7

WBC

103/uL

4.75 ± 0.64

4.05 ± 0.80

2.00 ± 1.80

1.71 ± 0.65

0.014

   NEU

%

42.03 ± 9.64

46.00 ± 11.59

24.00 ± 34.32

34.47 ± 23.53

0.583

   LYMP

%

51.73 ± 9.65

45.13 ± 12.34

68.13 ± 37.68

44.90 ± 10.57

0.475

   MONO

%

2.73 ± 0.65

3.28 ± 1.76

2.30 ± 3.81

3.40 ± 3.20

0.944

RBC

106/uL

9.10 ± 0.31

8.72 ± 0.35

7.59 ± 0.25

6.71 ± 1.93

0.044

HGB

g/dL

14.00 ± 1.04

13.35 ± 0.58

11.57 ± 0.45

10.27 ± 3.00

0.054

HCT

%

45.27 ± 2.20

43.68 ± 2.00

37.83 ± 1.26

34.07 ± 9.77

0.061

Retic

%

4.46 ± 1.80

3.75 ± 0.87

1.95 ± 2.73

4.92 ± 1.02

0.219

PLT

103/uL

854.00 ± 87.11

890.00 ± 69.15

1264.00 ± 405.28

1107.00 ± 330.45

0.212

  1. Data are presented as average ± SD (n = 3). WBC: white blood cell, NEU: neutrophils, LYMP: lymphocytes, MONO: monocytes, RBC: red blood cell, HGB: hemoglobin, HCT: hematocrit, Retic: reticulocyte, PLT: platelet, AST: aspartate aminotransferase, ALT: alanine aminotransferase, TP: total protein, BUN: blood urea nitrogen, Cr: creatinine.
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