Figure 1

Sleep-wake profiles produced by administration of ethanol in C57BL/6Slac mice. (A) Typical examples of polygraphic recordings and corresponding hypnograms illustrating changes of sleep over 7 h (20:00–03:00) following vehicle (upper panel) or ethanol (lower panel) administration. (B) Changes in NREM sleep, REM sleep, and wakefulness in mice treated with 3.0 g/kg ethanol. (C) Dose-response effects on total time spent in NREM sleep, REM sleep, and wakefulness for 5 h after administration of vehicle and ethanol. Values are mean ± SEM (n = 9–10). (B) *P < 0.05 or **P < 0.01 indicates significant differences compared with their own control as assessed by two-way ANOVA followed by Fisher’s least-significant difference (PLSD) test. (C) **P < 0.01 indicates significant differences compared with the control as assessed by non-paired, two-tailed Student’s t test. The letters “a, b, c, d” indicate different subsets among doses of ethanol as assessed by one-way ANOVA followed by Duncan’s multiple range test.