Figure 6
From: Adenosine A2A receptor mediates hypnotic effects of ethanol in mice
Sleep-wake profiles produced by administration of ethanol in A2AR WT and A2AR KO mice. (A,B) Changes in NREM sleep, REM sleep, and wakefulness in A2AR WT (A) and KO (B) mice treated with 3.0 g/kg ethanol. (C) Effect of ethanol on total time spent in NREM sleep, REM sleep, and wakefulness for 5 h after administration of vehicle and ethanol in A2AR WT and KO mice. Values are mean ± SEM (n = 8–9). (A,B) *P < 0.05 or **P < 0.01 indicates significant differences compared with their own control as assessed by two-way ANOVA followed by Fisher’s PLSD test. (C) **P < 0.01 indicates significant differences compared with their own control as assessed by two-tailed unpaired Student’s t test. P < 0.01 indicates significant differences between A2AR WT and KO mice performed using two-tailed unpaired Student’s t test.
