Figure 1
From: Modeling the Kinetics of Integrin Receptor Binding to Hepatic Extracellular Matrix Proteins
Repertoire of alpha and beta integrin subtype dimerization pairings. This diagram delineates the 24 possible integrin dimer species, classified by substrate type. For this study, of the integrins relevant to the CCl4 model, the collagen-binding β1 integrins and RGD-binding β1 and β3 receptors were evaluated. Binding here was treated as a two-step model with the α subunit binds ligand first, influencing ligand recognition and determinant of association kinetics. The β subunit binds second, creating bond stabilization and determining dissociation kinetics14, apropos to a divalent kinetics model with the α subunit being the high affinity site, and the β subunit as the low affinity site.
