Figure 6
From: Modeling the Kinetics of Integrin Receptor Binding to Hepatic Extracellular Matrix Proteins
Model description: (a), mass-action kinetics scheme of species variables. Divalent receptors bind ligand sequentially to α, β subunits, with Ki = k 2 /k 1 for equilibrium of initial binding event (C m ) and Kc = k 4 /k 3 for fully occupied ECMP-Integrin receptor complex (C d ). The receptor aggregation scheme incorporates divalent binding and receptor pairing such that half/fully occupied receptors can aggregate only with an unbound receptor [aggregation equilibrium constant Ka = k 6 /k 5]. Binding constants for an additional ECM ligand binding to unbound receptor in an aggregate pair are the same regardless of occupancy status of its paired receptor [population equilibrium constant is Kp = k 10 /k 9]. The equilibrium constant for adding a second ECM ligand to a singly bound receptor in any pair-configuration is Kx = k 8 /k 7. Adapted from Wanant and Quon (2000)28. (b), model species description.
