Table 2 Binding Rate Parameters.

From: Modeling the Kinetics of Integrin Receptor Binding to Hepatic Extracellular Matrix Proteins

Integrin Species

Initial Value (nM)

Binding Kinetic Parameters (kon[s−1M−1];koff[s−1])

Col I48,49

Col IV49

Fibronectin

von Willebrand factor A50

kon

koff

kon

koff

kon

koff

kon

koff

α1β148,49,51

0.0001

5.6 × 104

1.3 × 10−3

8.0 × 105

5.0 × 10−3

---

---

---

---

αVβ3

0.05

---

---

---

---

1.6 × 108

3.5 × 10−1

1.6 × 104

2.3 × 10−2

  1. Initial conditions and reaction rate parameters of kinetic models – collagens, glycoproteins and proteoglycans. Rates for binding ECM components relevant to the CCl4 model are delineated per cognate integrin receptor. From published literature initial values of integrin receptor species are derived and given in nanomolar; similarly, binding rate parameters are given in s−1M−1 for kon and s−1 for koff.
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