Table 5 Sensitivity Analysis.

From: Modeling the Kinetics of Integrin Receptor Binding to Hepatic Extracellular Matrix Proteins

Parameter

Description

Baseline

10 fold increase

10 fold decrease

% Change in Steady State

10 fold increase

10 fold decrease

Ka

Aggregation Constant

     

avb3 (vWF)

Aggregate Receptor Pair

0.0014422

0.0001595

0.00731635

−88.9417

4.07317

Single Divalent Receptor

0.047071

0.0496846

0.03206668

0.0555246

−31.8759

avb3 (Fn)

Aggregate Receptor Pair

0.0025167

0.0003024

0.00916465

−87.9828

2.64149

Single Divalent Receptor

0.0448266

0.0494085

0.0250326

0.102215

−44.1568

a1b1 (Col I)

Aggregate Receptor Pair

7.787 × 10−10

7.788 × 10−11

7.7855 × 10−9

−89.9997

899.743

Single Divalent Receptor

0.0001

0.0001

9.9988 × 10−5

1.4009 × 10−5

−0.0001401

Kp

Population of Empty Paired Receptors

     

avb3 (vWF)

Aggregate Receptor Pair

0.0014422

0.0012618

0.00144284

−12.5058

0.0466698

Single Divalent Receptor

0.047071

0.0470725

0.04706991

0.00319051

−0.0022229

avb3 (Fn)

Aggregate Receptor Pair

0.0025167

0.0022089

0.00252032

−12.2318

0.142716

Single Divalent Receptor

0.0448266

0.0448329

0.04482091

0.0140776

−0.0126299

a1b1 (Col I)

Aggregate Receptor Pair

7.787 × 10−10

7.489 × 10−10

7.7875 × 10−10

−3.83664

−4.768 × 10−5

Single Divalent Receptor

0.0001

0.0001

0.0001

−2.454 × 10−8

−1.34 × 10−10

Kx

Aggregate Receptor Saturation

     

avb3 (vWF)

Aggregate Receptor Pair

0.0014422

0.0010941

0.00144273

−24.1374

0.03937633

Single Divalent Receptor

0.047071

0.0470717

0.04707014

0.00154618

−0.0017387

avb3 (Fn)

Aggregate Receptor Pair

0.0025167

0.0019215

0.00251985

−23.650441

0.12406835

Single Divalent Receptor

0.0448266

0.0448308

0.04482188

0.00949427

−0.0104646

a1b1 (Col I)

Aggregate Receptor Pair

7.787 × 10−10

7.06 × 10−10

7.7875 × 10−10

−9.3388012

−7.855 × 10−5

Single Divalent Receptor

0.0001

0.0001

0.0001

−4.37 × 10−9

−2.26 × 10−10

Ki

Integrin Complex Formation

     

avb3 (vWF)

Aggregate Receptor Pair

0.0014422

0.0142873

2.8307 × 10−5

890.686233

−98.03722

Single Divalent Receptor

0.047071

0.0306523

0.04969114

−34.880649

5.56644996

avb3 (Fn)

Aggregate Receptor Pair

0.0025167

0.0206362

5.2505 × 10−5

719.962077

−97.91377

Single Divalent Receptor

0.0448266

0.0236912

0.04943082

−47.14931

10.2712401

a1b1 (Col I)

Aggregate Receptor Pair

7.787 × 10−10

9.496 × 10−9

1.3021 × 10−11

1119.42405

−98.327913

Single Divalent Receptor

0.0001

9.694 × 10−5

1 × 10−4

−3.0666187

−0.0017795

Kc

Single Divalent Receptor Saturation

     

avb3 (vWF)

Aggregate Receptor Pair

0.0014422

0.0002512

0.00269898

−82.584496

87.1478824

Single Divalent Receptor

0.047071

0.0426039

0.04702548

−9.4901208

−0.0966041

avb3 (Fn)

Aggregate Receptor Pair

0.0025167

0.0004241

0.00482601

−83.148576

91.7572123

Single Divalent Receptor

0.0448266

0.0410334

0.04467362

−8.4619004

−0.3412082

a1b1 (Col I)

Aggregate Receptor Pair

7.787 × 10−10

1.279 × 10−10

1.2887 × 10−9

−83.571112

65.4777672

Single Divalent Receptor

0.0001

9.695 × 10−5

9.9998 × 10−5

−3.0532152

−0.003242

  1. Sensitivity Analysis for Integrin Receptor Concentration. Sensitivity analysis was performed by modulating equilibrium binding constants, calculating the percent change in steady state value attained by the system. Values for CCl4 treatment groups used for analysis.
Back to article page