Figure 1
From: Acinar cells in the neonatal pancreas grow by self-duplication and not by neogenesis from duct cells
Follow-up of ElaCreERT R26-YFP mice during early postnatal period. Body weight (a), pancreas weight (b), ratio of pancreas weight over body weight (expressed as percentage) (c) and non-fasting glycaemia (d) of ElaCreERT R26-YFP mice were measured at indicated time points in non-TAM-treated mice (n = 8–14) and TAM-treated mice (n = 11–23). Data on glycaemia are expressed as mean ± 95% confidence intervals. All other results are expressed as mean ± SEM. (a–c) were analysed by 1-way ANOVA, followed by Bonferroni’s multiple comparison test (comparisons of interest: w1-w2, w2-w4, w1-w4; n1-w1, n4-w4, n1-n4. For Fig. 1c: n1-w1, n4-w4). Results are considered statistically significant when P < 0.05. *** or °°° P < 0.001. (°°°) indicates P-value compared to all previous time points. NS: not significant. Detailed information about numbers of analysed mice, cells and area can be found in Table 1.
