Figure 1 | Scientific Reports

Figure 1

From: Functional Activation of Osteoclast Commitment in Chronic Lymphocytic Leukaemia: a Possible Role for RANK/RANKL Pathway

Figure 1

%IBV/SV ratio in control subjects (white) overall CLL patients (black). This latter group is subdivided according to Binet A (pale grey), B (grey) and C (dark grey). CLL was associated with a significant bone erosion (**p < 0.01 vs controls) that was independent from Binet stage when the whole skeleton was analyzed (panel A), while it was related to clinical disease stage in the appendicular districts (panel B). Panel C shows whole body RBM glucose consumption in CLL patients and control subjects. In appendicular bones (Panel D), this same pattern was associated with a significant progressive trend in N-SUV (p < 0.05) between the different Binet stages and became higher than control value in Binet C patients (*p < 0.05). Panels E-F-G: Examples of RBM distributions in the three Binet stages, respectively. The expansion of RBM in proximal femur shafts is evident only in Binet C patient (red arrows).

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