Table 1 Mouse models of chronic otitis media discovered at MRC Harwell. All develop spontaneous chronic OM within a few weeks of birth.

From: A mouse-to-man candidate gene study identifies association of chronic otitis media with the loci TGIF1 and FBXO11

Name

Locus

Background

Discovery mechanism

Reference

Jeff (het)

Fbxo11

C3H/HeN

ENU mutagenesis

Hardisty-hughes et al.9

Junbo (het)

Evi1 (Mecom)

C3H/HeN

ENU mutagenesis

Parkinson et al.10

Tgif1 knockout

Tgif1

C57BL/6J

Knockout

Tateossian et al.28

Edison (hom)

Nisch

C3H/HeH

ENU mutagenesis

Crompton12

Back to article page