Table 3 Coefficient of correlation between variations (Δ) of biomarkers between baseline and 6-week (n = 123), 6-month (n = 108) and one-year (n = 93).

ΔPTH

XXXXX

Δb-ALP

−0.08 NS

XXXXX

ΔCTX

0.38  P < 0.0001

0.07 NS

XXXX

ΔOsteocalcin

−0.03 NS

0.31  P = 0.0004

0.15 NS

XXXXX

ΔP1NP

−0.14 NS

0.43  P < 0.0001

0.06 NS

0.52  P < 0.0001

XXXX

ΔTRAP-5b

0.04 NS

−0.26  P = 0.0036

0.20  P = 0.0247

−0.07 NS

−0.06 NS

XXXXX

6-month n = 108

ΔPTH

Δb-ALP

ΔCTX

Δosteocalcin

ΔP1NP

ΔTRAP-5b

ΔPTH

XXXXX

Δb-ALP

0.11 NS

XXXXX

ΔCTX

0.39  P < 0.0001

0.38  P < 0.0001

XXXX

ΔOsteocalcin

0.27  P = 0.0049

0.26  P = 0.007

0.32  P = 0.0008

XXXXX

ΔP1NP

0.07 NS

0.44  P < 0.0001

0.48  P < 0.0001

0.54  P < 0.0001

XXXX

ΔTRAP-5b

0.04 NS

0.03 NS

0.27  P = 0.0045

0.07 NS

0.24  P = 0.013

XXXXX

One-year n = 93

ΔPTH

Δb-ALP

ΔCTX

Δosteocalcin

ΔP1NP

ΔTRAP-5b

ΔPTH

XXXXX

Δb-ALP

0.29  P = 0.0054

XXXXX

ΔCTX

0.47  P < 0.0001

0.44  P < 0.0001

XXXX

ΔOsteocalcin

0.36  P = 0.0004

0.41  P < 0.0001

0.43  P < 0.0001

XXXXX

ΔP1NP

0.40  P = 0.0001

0.68  P < 0.0001

0.59  P < 0.0001

0.65  P < 0.0001

XXXX

ΔTRAP-5b

0.08 NS

0.14 NS

0.36  P = 0.0004

0.31  P = 0.0021

0.37  P = 0.0003

XXXXX