Table 4 Head-to-head comparison of biomarkers variations (increaser/stable/decliner) according to their respective critical difference.

From: Variations of parathyroid hormone and bone biomarkers are concordant only after a long term follow-up in hemodialyzed patients

6-week (n = 93)

Increased b-ALP (Δb-ALP >  + 23%)

b-ALP stable (Δb-ALP within 23%)

Decreased b-ALP (Δb-ALP > −23%)

Increased PTH (ΔPTH >  + 43%)

1 (1%)

13 (14%)

1 (1%)

PTH stable (ΔPTH within 43%)

14 (15%)

53 (56%)

1 (1%)

Decreased PTH (ΔPTH > −43%)

4 (4%)

4 (4%)

2 (2%)

One-year (n = 93)

Increased b-ALP (Δb-ALP >  + 23%)

b-ALP stable (Δb-ALP within 23%)

Decreased b-ALP (Δb-ALP > −23%)

Increased PTH (ΔPTH >  + 43%)

17 (18%)

7 (8%)

0 (0%)

PTH stable (ΔPTH within 43%)

26 (28%)

27 (29%)

1 (1%)

Decreased PTH (ΔPTH > −43%)

4 (4%)

7 (8%)

4 (4%)

6-week (n = 93)

Increased P1NP (P1NP > + 32%)

P1NP stable (P1NP within 32%)

Decreased P1NP (P1NP > −32%)

Increased PTH (ΔPTH >  + 43%)

4 (4%)

9 (10%)

2 (2%)

PTH stable (ΔPTH within 43%)

16 (17%)

50 (53%)

2 (2%)

Decreased PTH (ΔPTH > −43%)

5 (5%)

2 (2%)

3 (3%)

One-year (n = 93)

Increased P1NP (P1NP > + 32%)

P1NP stable (P1NP within 32%)

Decreased P1NP (P1NP > −32%)

Increased PTH (ΔPTH >  + 43%)

19 (20%)

5 (5%)

0 (0%)

PTH stable (ΔPTH within 43%)

25 (28%)

28 (30%)

1 (1%)

Decreased PTH (ΔPTH > −43%)

3 (3%)

7 (7%)

5 (5%)

6-week (n = 93)

Increased TRAP-5b (TRAP-5b > + 24%)

TRAP-5b stable (TRAP-5b within 24%)

Decreased TRAP-5b (TRAP-5b > −24%)

Increased PTH (ΔPTH > + 43%)

3 (3%)

8 (9%)

4 (4%)

PTH stable (ΔPTH within 43%)

12 (13%)

48 (51%)

8 (9%)

Decreased PTH (ΔPTH > −43%)

2 (2%)

3 (3%)

5 (5%)

One-year (n = 93)

Increased TRAP-5b (TRAP-5b > + 24%)

TRAP-5b stable (TRAP-5b within 24%)

Decreased TRAP-5b (TRAP-5b > −24%)

Increased PTH (ΔPTH > + 43%)

4 (4%)

16 (17%)

4 (4%)

PTH stable (ΔPTH within 43%)

10 (11%)

29 (32%)

15 (16%)

Decreased PTH (ΔPTH > −43%)

1 (1%)

5 (5%)

9 (10%)

6-week (n = 93)

Increased P1NP (P1NP > + 32%)

P1NP stable (P1NP within 32%)

Decreased P1NP (P1NP > −32%)

Increased b-ALP (Δb-ALP > + 23%)

9 (10%)

7 (7%)

3 (3%)

b-ALP stable (Δb-ALP within 43%)

15 (16%)

54 (58%)

1 (1%)

Decreased b-ALP (Δb-ALP > −43%)

1 (1%)

0 (0%)

3 (3%)

One-year (n = 93)

Increased P1NP (P1NP > + 32%)

P1NP stable (P1NP within 32%)

Decreased P1NP (P1NP > −32%)

Increased b-ALP (Δb-ALP > + 23%)

33 (35%)

13 (14%)

1 (1%)

b-ALP stable (Δb-ALP within 43%)

14 (15%)

25 (27%)

2 (2%)

Decreased b-ALP (Δb-ALP > −43%)

0 (0%)

2 (2%)

3 (3%)

6-week (n = 93)

Increased TRAP-5b (TRAP-5b > + 24%)

TRAP-5b stable (TRAP-5b within 24%)

Decreased TRAP-5b (TRAP-5b > −24%)

Increased b-ALP (Δb-ALP > + 23%)

4 (4%)

5 (5%)

10 (11%)

b-ALP stable (Δb-ALP within 43%)

11 (12%)

52 (56%)

7 (7%)

Decreased b-ALP (Δb-ALP > −43%)

2 (2%)

2 (2%)

0 (0%)

One-year (n = 93)

Increased TRAP-5b (TRAP-5b > + 24%)

TRAP-5b stable (TRAP-5b within 24%)

Decreased TRAP-5b (TRAP-5b > −24%)

Increased b-ALP (Δb-ALP > + 23%)

11 (12%)

30 (32%)

6 (6%)

b-ALP stable (Δb-ALP within 43%)

4 (4%)

20 (21%)

17 (18%)

Decreased b-ALP (Δb-ALP > −43%)

0 (0%)

0 (0%)

5 (5%)

6-week (n = 93)

Increased TRAP-5b (TRAP-5b > + 24%)

TRAP-5b stable (TRAP-5b within 24%)

Decreased TRAP-5b (TRAP-5b > −24%)

Increased P1NP (ΔP1NP > + 32%)

8 (9%)

9 (10%)

8 (9%)

P1NP stable (ΔP1NP within 32%)

8 (9%)

48 (52%)

5 (5%)

Decreased P1NP (ΔP1NP > −43%)

1 (1%)

2 (2%)

4 (4%)

One-year (n = 93)

Increased TRAP-5b (TRAP-5b > + 24%)

TRAP-5b stable (TRAP-5b within 24%)

Decreased TRAP-5b (TRAP-5b > −24%)

Increased P1NP (ΔP1NP > + 32%)

13 (14%)

27 (29%)

7 (7%)

P1NP stable (ΔP1NP within 32%)

2 (2%)

22 (23%)

16 (17%)

Decreased P1NP (ΔP1NP > −43%)

0 (0%)

1 (1%)

5 (5%)

  1. PTH versus b-ALP (6-week).
  2. Perfect concordance (bold cases): 56/93 = 60.2%.
  3. Discordance (roman cases): 32/93 = 34.4%.
  4. Severe discordance (italic cases): 5/93 = 5.4%.
  5. Percentage of perfect concordance (bold cases) excluding stable patients (the central bold case, n = 53)): 3/40 = 7.5%.
  6. PTH versus b-ALP (one-year).
  7. Perfect concordance (bold cases): 48/95 = 51.6%.
  8. Discordance (roman cases): 41/93 = 44.1%.
  9. Severe discordance (italic cases): 4:93 = 4.3%.
  10. Percentage of perfect concordance (bold cases) excluding stable patients (the central bold case, n = 27)): 21/66 = 31.8%.
  11. PTH versus P1NP (6-week).
  12. Perfect concordance (bold cases): 57/93 = 61.3%.
  13. Discordance (roman cases): 29/93 = 31.2%.
  14. Severe discordance (italic cases): 7/93 = 7.5%.
  15. Percentage of perfect concordance (bold cases) excluding stable patients (the central bold case, n = 50)): 7/43 = 16.3%.
  16. PTH versus P1NP (one-year).
  17. Perfect concordance (bold cases): 52/93 = 55.9%.
  18. Discordance (roman cases): 38/93 = 40.9%.
  19. Severe discordance (italic cases): 3/93 = 3.2%.
  20. Percentage of perfect concordance (bold cases) excluding stable patients (the central bold case, n = 28)): 24/65 = 36.9%.
  21. PTH versus TRAP-5b (6-week).
  22. Perfect concordance (bold cases): 56/93 = 60.2%.
  23. Discordance (roman cases): 31/93 = 33.3%.
  24. Severe discordance (italic cases): 6/93 = 6.5%.
  25. Percentage of perfect concordance (bold cases) excluding stable patients (the central bold case, n = 48)): 8/45 = 17.8%.
  26. PTH versus TRAP-5b (one-year).
  27. Perfect concordance (bold cases): 42/93 = 45.2%.
  28. Discordance (roman cases): 46/93 = 49.5%.
  29. Severe discordance (italic cases): 5/93 = 5.4%.
  30. Percentage of perfect concordance (bold cases) excluding stable patients (the central bold case, n = 29)): 13/64 = 20.3%.
  31. b-ALP versus P1NP (6-week).
  32. Perfect concordance (bold cases): 66/93 = 71%.
  33. Discordance (roman cases): 23/93 = 24.7%.
  34. Severe discordance (italic cases): 4/93 = 4.3%.
  35. Percentage of perfect concordance (bold cases) excluding stable patients (the central bold case, n = 54)): 12/39 = 30.8%.
  36. b-ALP versus P1NP (one-year).
  37. Perfect concordance (bold cases): 61/93 = 65.6%.
  38. Discordance (roman cases): 31/93 = 33.3%.
  39. Severe discordance (italic cases): 1/93 = 1.1%.
  40. Percentage of perfect concordance (bold cases) excluding stable patients (the central bold case, n = 25)): 36/68 = 52.9%.
  41. b-ALP versus TRAP 5-b (6-week).
  42. Perfect concordance (bold cases): 56/93 = 60.2%.
  43. Discordance (roman cases): 25/93 = 26.9%.
  44. Severe discordance (italic cases): 12/93 = 12.9%.
  45. Percentage of perfect concordance (bold cases) excluding stable patients (the central bold case, n = 52)): 4/41 = 9.8%.
  46. b-ALP versus TRAP 5-b (one-year).
  47. Perfect concordance (bold cases): 36/93 = 38.7%.
  48. Discordance (roman cases): 51/93 = 54.8%.
  49. Severe discordance (italic cases): 6/93 = 6.5%.
  50. Percentage of perfect concordance (bold cases) excluding stable patients (the central bold case, n = 20)): 16/73 = 21.9%.
  51. P1NP versus TRAP 5b (6-week).
  52. Perfect concordance (bold cases): 60/93 = 64.5%.
  53. Discordance (roman cases): 24/93 = 25.8%.
  54. Severe discordance (italic cases): 9/93 = 9.7%.
  55. Percentage of perfect concordance (bold cases) excluding stable patients (the central bold case, n = 48)): 12/45 = 26.7%.
  56. P1NP versus TRAP 5-b (one-year).
  57. Perfect concordance (bold cases): 40/93 = 43.0%.
  58. Discordance (roman cases): 46/93 = 49.5%.
  59. Severe discordance (italic cases): 7/93 = 7.5%.
  60. Percentage of perfect concordance (bold cases) excluding stable patients (the central bold case, n = 22)): 18/71 = 25.3%.
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