Table 2 Univariate and logistic multivariable regression analysis of the association of AFP levels with tumor cell differentiation.

From: The prognostic correlation of AFP level at diagnosis with pathological grade, progression, and survival of patients with hepatocellular carcinoma

Variable

pathological grade

χ2 test

P

logistic regression analysis

P

Well/Moderate

Poor/Anaplastic

 

(n = 3073) N (%)

(n = 723) N (%)

    

Sex

  

0.151

0.698

 

NI

Male

2388 (77.7)

557 (77.0)

    

Female

685 (22.3)

166 (23.0)

    

Age

  

<0.001

0.992

 

NI

<60

1365 (44.4)

321 (44.4)

    

≥60

1708 (55.6)

402 (55.6)

    

Race

  

31.811

<0.001

 

<0.001

White

2102 (68.4)

430 (59.5)

  

Reference

 

Black

370 (12.0)

83 (11.5)

  

0.983 (0.756–1.277)

0.895

Other*

601 (19.6)

210 (29.0)

  

1.633 (1.346–1.980)

<0.001

Fibrosis

  

4.767

0.029

0.822 (0.687–0.984)

0.032

F0†

885 (28.8)

238 (32.9)

    

F1††

2188 (71.2)

485 (67.1)

    

AFP

  

79.079

<0.001

2.559 (2.075–3.157)

<0.001

Negative

1044 (34.0)

123 (17.0)

    

Positive

2029 (66.0)

600 (83.0)

    

Marital Status

  

0.028

0.867

 

NI

Married

1847 (60.1)

437 (60.4)

    

Non-married#

1226 (39.9)

286 (39.6)

    
  1. *Other includes American Indian/Alaska native, and Asian/Pacific Islander.
  2. †F0, equivalent to Ishak score 0–4.
  3. ††F1, equivalent to Ishak score 5–6.
  4. #Non-married includes widowed, never married, divorced, separated, unmarried, and domestic partner. NI: not included in the logistic multivariable regression analysis.
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