Table 1 The clinical and pathological data for the cSCC patients with and without the EGFR-PPARGC1A fusion gene.
From: Chronic sun exposure-related fusion oncogenes EGFR-PPARGC1A in cutaneous squamous cell carcinoma
No. | Age | Sex | Diagnosis | Duration | Region | Size | Appearance | SCC antigen | Genesis | T | N | M | Stage | EGFR-PPARGC1A | FGFR3-TACC3 | AML4-ALK | NSD3-NUT | GOLM1-MAK10 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 79 | M | AK | 36 | cheek | 1 cm | erythema |  |  | is | 0 | 0 | 0 | + | − | − | − | − |
2 | 88 | M | Bowen | 0 | cheek | 1 cm | tumor | 1.6 |  | is | 0 | 0 | 0 | + | − | − | − | − |
3 | 93 | F | AK | 12 | cheek | 1 cm | tumor | 0.9 |  | is | 0 | 0 | 0 | − | − | − | − | − |
4 | 73 | M | AK |  | foot | 2 cm | tumor | 0.6 |  | is | 0 | 0 | 0 | − | − | − | − | − |
5 | 68 | F | AK | 48 | hand | 3.3 × 2.2 cm | tumor | 0.5 |  | is | 0 | 0 | 0 | + | − | − | − | − |
6 | 81 | M | Bowen |  | cheek | 1.2 × 1.0 cm | erythema |  |  | is | 0 | 0 | 0 | − | − | − | − | − |
7 | 90 | F | AK | 1 | head | 1.2 cm | tumor | 1.1 |  | is | 0 | 0 | 0 | + | − | − | − | − |
8 | 68 | M | SCC | 24 | hand | 0.5 cm | ulcer | 1.2 | burn | 1 | 0 | 0 | I | + | − | − | − | − |
9 | 87 | F | SCC |  | finger | 1 cm | tumor | 1 |  | 1 | 0 | 0 | I | − | − | − | − | − |
10 | 91 | F | SCC |  | cheek | 1 cm | tumor |  |  | 1 | 0 | 0 | I | + | − | − | − | − |
11 | 95 | F | SCC |  | cheek | 2 cm | tumor | 0.9 |  | 1 | 0 | 0 | I | − | − | − | − | − |
12 | 94 | F | SCC | 60 | cheek |  | tumor |  |  | 1 | 0 | 0 | I | − | − | − | − | − |
13 | 86 | F | SCC | 12 | cheek | 1.2 × 1.5 cm | tumor |  |  | 1 | 0 | 0 | I | − | − | − | − | − |
14 | 82 | F | SCC | 4 | lip | 1 cm | tumor | 1.1 |  | 1 | 0 | 0 | I | − | − | − | − | − |
15 | 64 | M | SCC |  | cheek | 1.2 × 0.8 cm | tumor | 0.6 | burn | 1 | 0 | 0 | I | − | − | − | − | − |
16 | 54 | F | SCC | 1 | eye lid | 2 cm | tumor | 0.9 |  | 1 | 0 | 0 | I | − | − | − | − | − |
17 | 82 | M | SCC | 5 | foot | 1.1 × 1.0 cm | tumor | 1.3 |  | 1 | 0 | 0 | I | − | − | − | − | − |
18 | 81 | M | SCC | 7 | finger | 2 × 1.5 cm | tumor | 4.2 | trauma | 1 | 0 | 0 | I | + | − | − | − | − |
19 | 67 | M | SCC | 36 | inguinal | 2 cm | tumor | 1 |  | 1 | 0 | 0 | I | − | − | − | − | − |
20 | 77 | M | SCC | 3 | hand | 1.0 × 1.2 cm | tumor | 1.1 |  | 1 | 0 | 0 | I | − | − | − | − | − |
21 | 86 | M | SCC | 4 | nose | 0.5 cm | tumor | 2.4 |  | 1 | 0 | 0 | I | − | − | − | − | − |
22 | 89 | M | SCC | 24 | lip | 1 cm | tumor | 2.2 |  | 1 | 0 | 0 | I | + | − | − | − | − |
23 | 77 | M | SCC |  | hand | 2 cm | tumor | 1.4 |  | 1 | 0 | 0 | I | − | − | − | − | − |
24 | 66 | M | SCC | 12 | ear | 0.7 cm | erosion | 1.1 |  | 1 | 0 | 0 | I | + | − | − | − | − |
25 | 72 | M | SCC | 6 | ear | 1 cm | tumor | 1 |  | 1 | 0 | 0 | I | − | − | − | − | − |
26 | 63 | M | SCC | 1 | nose | 0.5 cm | tumor | 1.7 |  | 1 | 0 | 0 | I | + | − | − | − | − |
27 | 72 | M | SCC | 0 | cheek | 0.8 cm | tumor | 1.4 |  | 1 | 0 | 0 | I | − | − | − | − | − |
28 | 73 | F | SCC | 3 | head | 2 cm | tumor | 0.9 |  | 1 | 0 | 0 | I | − | − | − | − | − |
29 | 91 | F | SCC | 36 | cheek | 1 cm | tumor | 0.8 |  | 1 | 0 | 0 | I | + | − | − | − | − |
30 | 81 | F | SCC | 3 | cheek | 0.3 cm | tumor |  |  | 1 | 0 | 0 | I | − | − | − | − | − |
31 | 83 | M | SCC | 12 | cheek | 1.1×0.8 cm | tumor | 1.7 |  | 1 | 0 | 0 | I | + | − | − | − | − |
32 | 74 | M | SCC | 3 | hand | 1 cm | tumor |  |  | 1 | 0 | 0 | I | − | − | − | − | − |
33 | 87 | F | SCC | 6 | cheek | 1.2×0.8 cm | tumor | 1.2 |  | 1 | 0 | 0 | I | − | − | − | − | − |
34 | 82 | M | SCC | 6 | head | 1 cm | tumor | 0.9 |  | 1 | 0 | 0 | I | + | + | − | − | − |
35 | 72 | M | SCC | 12 | foot | 0.5 cm | ulcer | 0.8 |  | 1 | 0 | 0 | I | + | − | − | − | − |
36 | 76 | M | SCC | 6 | hand | 0.7 cm | tumor | 2.9 |  | 1 | 0 | 0 | I | − | − | − | − | − |
37 | 85 | F | SCC | 600 | cheek | 2 cm | tumor | 1.5 |  | 1 | 0 | 0 | I | + | − | − | − | − |
38 | 71 | M | SCC | 96 | hand | 0.8 cm | tumor | 1.5 |  | 1 | 0 | 0 | I | − | − | − | − | − |
39 | 94 | F | SCC | 3 | cheek | 2 cm | tumor | 1.2 |  | 1 | 0 | 0 | I | − | − | − | − | − |
40 | 86 | M | SCC | 2 | hand | 1 cm | tumor | 2.5 |  | 1 | 0 | 0 | I | − | − | − | − | − |
41 | 80 | F | SCC |  | hand | 1 cm | tumor | 2.5 |  | 1 | 0 | 0 | I | + | − | − | − | − |
42 | 90 | M | SCC | 3 | cheek | 1 cm | tumor | 2.2 |  | 1 | 0 | 0 | I | − | − | − | − | − |
43 | 77 | F | SCC | 0 | cheek | 0.3 cm | tumor | 0.5 |  | 1 | 0 | 0 | I | − | + | − | − | − |
44 | 95 | F | SCC | 3 | ear | 1 cm | tumor | 3.1 |  | 1 | 0 | 0 | I | + | − | − | − | − |
45 | 76 | M | SCC | 4 | cheek | 1.3 × 1.0 cm | tumor | 1.2 |  | 1 | 0 | 0 | I | − | − | − | − | − |
46 | 91 | F | SCC |  | hand | 1.5 cm | tumor | 1.9 |  | 1 | 0 | 0 | I | − | − | − | − | − |
47 | 84 | M | SCC | 12 | ear | 0.8 × 0.7 cm | tumor | 1 |  | 1 | 0 | 0 | I | − | − | − | − | − |
48 | 72 | M | SCC | 6 | cheek | 1.2 × 1.3 cm | tumor | 1.1 |  | 1 | 0 | 0 | I | − | − | − | − | − |
49 | 78 | M | SCC | 2 | cheek | 1.1 cm | tumor | 1.5 |  | 1 | 0 | 0 | I | − | − | − | − | − |
50 | 90 | M | SCC | 12 | head | 2 cm | erosion | 1.7 |  | 2 | 0 | 0 | II | − | − | − | − | − |
51 | 85 | M | SCC |  | head | 4.5 × 4.6 cm | tumor | 0.7 |  | 2 | 0 | 0 | II | + | − | − | − | − |
52 | 91 | F | SCC | 2 | inguinal | 3.5 × 4 cm | tumor | 5.8 |  | 2 | 0 | 0 | II | − | − | − | − | − |
53 | 66 | M | SCC | 0 | foot | 5.5 × 2 cm | ulcer | 1.5 | burn | 2 | 0 | 0 | II | − | − | − | − | − |
54 | 59 | M | SCC |  | foot | 2 cm | tumor | 0.9 |  | 2 | 0 | 0 | II | + | − | − | − | − |
55 | 76 | F | SCC | 48 | lip | 3 cm | tumor | 3.2 |  | 2 | 0 | 0 | II | − | − | − | − | − |
56 | 76 | M | SCC | 48 | head | 2.1 × 1.3 cm | tumor | 0.6 | burn | 2 | 0 | 0 | II | + | − | − | − | − |
57 | 78 | M | SCC | 4 | elbow | 10 cm | tumor | 1.4 | trauma | 2 | 0 | 0 | II | + | − | − | − | − |
58 | 85 | M | SCC | 1 | finger | 2.5 × 2.0 cm | erosion | 4.3 |  | 2 | 0 | 0 | II | + | − | − | − | − |
59 | 91 | F | SCC |  | nose | 2.1 × 1.6 cm | tumor | 1.4 |  | 2 | 0 | 0 | II | − | − | − | − | − |
60 | 81 | M | SCC | 3 | ear | 2 × 2 cm | tumor | 2.3 |  | 2 | 0 | 0 | II | − | − | − | − | − |
61 | 75 | F | SCC | 3 | lip | 2 cm | tumor | 0.8 |  | 2 | 0 | 0 | II | + | − | − | − | − |
62 | 72 | M | SCC | 1 | foot | 4 cm | ulcer | 3 | trauma | 2 | 0 | 0 | II | − | − | − | − | − |
63 | 53 | M | SCC | 6 | lip | 2 cm | tumor | 0.8 |  | 2 | 0 | 0 | II | − | − | − | − | − |
64 | 76 | M | SCC |  | hand | 2 cm | tumor | 1.2 |  | 2 | 0 | 0 | II | − | − | − | − | − |
65 | 71 | F | SCC | 120 | inguinal | 2 cm | ulcer | 1.7 |  | 2 | 0 | 0 | II | − | − | − | − | − |
66 | 85 | M | SCC | 1 | neck | 2 cm | tumor |  |  | 2 | 0 | 0 | II | + | − | − | − | − |
67 | 90 | M | SCC | 120 | abdomen | 3.5 × 2.5 cm | tumor | 0.8 |  | 2 | 0 | 0 | II | − | − | − | − | − |
68 | 59 | F | SCC | 48 | abdomen | 8 cm | tumor | 11.5 |  | 2 | 0 | 0 | II | − | − | − | − | − |
69 | 69 | M | SCC | 24 | knee | 8 cm | scar | 3.1 | burn | 2 | 0 | 0 | II | − | − | − | − | − |
70 | 61 | M | SCC | 4 | joe | 2 cm | tumor | 1.5 |  | 2 | 0 | 0 | II | − | − | − | − | − |
71 | 79 | M | SCC | 48 | head | 2 cm | tumor | 2.4 | burn | 2 | 0 | 0 | II | − | − | − | − | − |
72 | 87 | M | SCC | 24 | hand | 2 cm | tumor | 1.3 |  | 2 | 0 | 0 | II | − | − | − | − | − |
73 | 84 | F | SCC | 6 | foot | 2 cm | tumor | 0.5 |  | 2 | 0 | 0 | II | − | − | − | − | − |
74 | 89 | F | SCC | 24 | finger | 2 × 1.5 cm | tumor | 0.8 |  | 2 | 0 | 0 | II | − | − | − | − | − |
75 | 91 | F | SCC | 2 | foot | 2 × 1.5 cm | tumor | 1.3 |  | 2 | 0 | 0 | II | + | − | − | − | − |
76 | 70 | M | SCC | 60 | head | 3 cm | tumor | 1.4 | burn | 2 | 0 | 0 | II | − | − | − | − | − |
77 | 85 | F | SCC | 4 | head | 2.5 cm | tumor | 1.2 |  | 2 | 0 | 0 | II | + | − | − | − | − |
78 | 94 | M | SCC | 12 | foot | 7.5 cm | erosion | 1.9 |  | 2 | 0 | 0 | II | − | − | − | − | − |
79 | 56 | M | SCC | 0.5 | nose | 2.5 cm | tumor | 1.4 |  | 2 | 0 | 0 | II | − | − | − | − | − |
80 | 83 | M | SCC | 12 | ear | 2.9 × 2.0 cm | tumor | 0.7 |  | 2 | 0 | 0 | II | − | − | − | − | − |
81 | 88 | F | SCC | 24 | head | 2.5 × 1.7 cm | tumor | 1.1 | burn | 2 | 0 | 0 | II | − | − | − | − | − |
82 | 78 | F | SCC |  | cheek | 2.5 cm | tumor | 0.8 |  | 2 | 0 | 0 | II | − | − | − | − | − |
83 | 69 | M | SCC | 60 | back | 2 cm | tumor | 9.4 |  | 2 | 1 | 0 | III | − | − | − | − | − |
84 | 75 | M | SCC | 3 | cheek | 4 cm | tumor | 2 |  | 2 | 1 | 0 | III | + | − | − | − | − |
85 | 91 | F | SCC | 12 | head | 2.7 cm | tumor | 1.8 |  | 2 | 1 | 0 | III | − | − | − | − | − |
86 | 94 | F | SCC | 6 | head | 4 × 3 cm | tumor | 2.9 |  | 3 | 0 | 0 | III | − | − | − | − | − |
87 | 76 | M | SCC | 3 | lip | 4.5 × 2 cm | tumor | 1.4 |  | 2 | 1 | 0 | III | + | − | − | − | − |
88 | 44 | M | SCC | 3 | foot |  | tumor | 2 | burn | 4 | 1 | 0 | III | − | − | − | − | − |
89 | 73 | F | SCC | 3 | head | 0.8 × 0.8 cm | ulcer | 1.8 |  | 1 | 1 | 0 | III | − | − | − | − | − |
90 | 83 | M | SCC | 1 | cheek | 2.2 cm | tumor | 2.4 |  | x | 1 | 0 | III | + | − | − | − | − |
91 | 82 | F | SCC | 1 | cheek | 3 × 2 cm | tumor | 1.5 |  | 3 | 0 | 0 | III | + | − | − | − | − |
92 | 63 | F | SCC | 0 | head |  |  | 0.8 |  | 3 | 0 | 0 | III | − | − | − | − | − |
93 | 71 | F | SCC | 0 | cheek |  |  | 1.1 |  | x | 1 | 0 | III | − | − | − | − | − |
94 | 84 | M | SCC | 36 | ear |  | ulcer | 1.4 |  | 4 | 0 | 0 | III | − | − | − | − | − |
95 | 54 | F | SCC | 3 | head | 8 × 7 cm | tumor | 3.9 | burn | 4 | 0 | 0 | IV | − | − | − | − | − |
96 | 68 | M | SCC | 6 | foot | 21.1 × 7.8 cm | tumor | 1.3 |  | x | 2 | 0 | IV | − | − | − | − | − |
97 | 83 | M | SCC | 1 | foot | 0.5 × 0.3 cm | tumor | 0.5 |  | 1 | 1 | 1 | IV | + | − | − | − | − |
98 | 80 | M | SCC | 0 | cheek |  |  | 3.7 |  | 1 | 2 | 0 | IV | − | − | − | − | − |
99 | 81 | M | SCC | 48 | foot |  | tumor |  |  | x | 1 | 1 | IV | − | − | − | − | − |
100 | 95 | F | SCC | 8 | cheek | 2 cm | ulcer |  |  | 3 | x | x | X | − | − | − | − | − |
101 | 71 | M | SCC |  | nose |  | ulcer |  |  |  |  |  | X | − | − | − | − | − |
102 | 94 | F | SCC | 12 | cheek | 2 cm | tumor | 1.2 |  | 2 |  |  | X | − | − | − | − | − |
