Figure 4 | Scientific Reports

Figure 4

From: Exosomes secreted by human adipose mesenchymal stem cells promote scarless cutaneous repair by regulating extracellular matrix remodelling

Figure 4

ASC-derived exosomes affected the expression of genes associated with scarless wound healing in dermal fibroblasts. (A) mRNA expression of α-SMA, COL1A1, COL3A1, MMP1, MMP3, TIMP1, TGF-β1 and TGF-β3 in human fibroblasts treated with 0, 25, 50 or 100 µg/mL ASC-Exos for 24 hours. (B) Western blot analysis of the expression of α-SMA, Collagen I, Collagen III, MMP1, MMP3, TIMP1, TGF-β1and TGF-β3 in fibroblasts treated with ASC-Exos (100 µg/mL) for 24 hours. (C) Densitometric analysis of the western blot bands. Results are presented as mean ± SD; n = 3; *p < 0.05, **p < 0.01, ***p < 0.001, compared with the control groups.

Back to article page