Table 1 Table showing baseline patient characteristics of forty AML patients included in the study, stratified by low (<0.45) and high (≥0.45) composite IDO-1 score (The cut-off point of 0.45 was derived after a ROC analysis).

From: A novel immunohistochemical score to predict early mortality in acute myeloid leukemia patients based on indoleamine 2,3 dioxygenase expression

Patient characteristics (n  =  40)

Number of patients (%)

Composite IDO-1 score  <  0.45 (%)

Composite IDO-1 score ≥0.45 (%)

Median censored OS (in days)

P value

Age

  <55

13 (32.5)

9 (69.2)

4 (30.8)

747

0.02*

  56–74

19 (47.5)

5 (26.3)

14 (73.7)

284

0.6

  >75

5 (12.5)

1 (20)

4 (80)

155

0.06

Sex

  Male

16 (40)

3 (18.8)

13 (81.2)

217

0.02*

  Female

24 (60)

12 (50)

12 (50)

553

 

 Race

  Caucasian

22 (55)

6 (27.3)

16 (72.7)

317

0.07

  African- American

18 (45)

9 (50)

9 (50)

331

 

FAB subtype

  M0

0 (0)

0 (0)

0 (0)

—

—

  M1

6 (15)

1 (16.7)

5 (83.3)

340

0.5

  M2

5 (12.5)

1 (20)

4 (80)

282

0.3

  M3

1 (2.5)

1 (100)

0 (0)

—

0.08

  M4

5 (12.5)

4 (80)

1 (20)

—

0.001*

  M5

8 (20)

4 (50)

4 (50)

665

0.5

  M6

2 (5)

0 (0)

2 (100)

151

0.17

  M7

0 (0)

0 (0)

0 (0)

—

—

  AML with myelodysplasia-related changes

11 (27.5)

2 (18.2)

9 (81.8)

207

0.005*

  FAB subtype unknown

2 (5)

2 (100)

0 (0)

—

0.4

Risk category (based on cytogenetics/mutational analysis)

  Good

4 (7.5)

3 (75)

1 (25)

—

 

  Intermediate

27 (80)

12 (44.4)

15 (55.6)

377

 

  Poor

9 (12.5)

0 (0)

9 (100)

147

0.002*

Allogeneic stem cell transplant

  Yes

6 (15)

4 (66.7)

2 (33.3)

—

0.0005*

  No

30 (75)

10 (33.3)

20 (66.7)

217

 

  Unknown

4 (10)

1 (25)

3 (75)

711

 

Treatment

  Standard induction ± maintenance

29 (72.5)

13 (44.8)

16 (55.2)

500

0.07

  Hypomethylating agents

4 (10)

1 (25)

3 (75)

253

 

  Untreated/unknown

7 (17.5)

1 (14.3)

6 (85.7)

207

 

Remission

  Yes

20 (50)

13 (65)

7 (35)

756

  <  0.0001*

  No

19 (47.5)

1 (5.3)

18 (94.7)

147

 

  Unknown

1 (2.5)

1 (100)

0 (0)

—

 

Relapse (If remission was achieved)

  Yes

10 (25)

6 (60)

4 (40)

625

<0.0001*

  No

10 (25)

7 (70)

3 (30)

—

 
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