Figure 1
FN and TNC are expressed in angiogenic blood vessels of human tumours. (top) CD31 immunohistochemical staining (brown) of human HNSCC counterstained with haematoxylin (blue). Double immunofluorescent staining, as indicated, of FN with CD31 or TNC on adjacent sections of the same tumour are shown. Separate images for the FN/CD31 and FN/TNC channels, are shown as Supplementary Information (Fig. S1). Nuclei are stained with DRAQ5 (blue). FN-expressing vessels (yellow arrows) and TNC-positive/FN-negative vessels (white arrows) are indicated. Dotted squares (left images) depict zoomed areas (right images). Corresponding areas of the same vessel are encircled. Bars = 100 µm.
