Figure 7
Schematic of TNC-regulated pro-angiogenic signalling in endothelial cells. TNC inhibits endothelial cell adhesion, spreading and stress fibre formation (F-actin polymerization). This effect can lead to anoikis, or be counterbalanced by upregulation of Wnt target genes including FN and VEGFA. Autocrine FN (EDA) drives α5β1-dependent FN fibrillogenesis, promotes junction stabilization and impacts capillary morphogenesis.
