Figure 6 | Scientific Reports

Figure 6

From: Environmental perturbation of the circadian clock during pregnancy leads to transgenerational mood disorder-like behaviors in mice

Figure 6The alternative text for this image may have been generated using AI.

Protein interaction networks involving proteins that are differentially expressed in the hypothalamus of CCD F1 female mice. (a) Network of cell-to-cell signaling and interaction, nervous system development and function, and cell morphology. (b) Network of behavior, cardiovascular development and function, and organ development. (c) Network of endocrine disorders, metabolic disease, and endocrine system development and function. In panels a, b and c, red symbols represent up-regulated proteins, and green symbols represent down-regulated proteins. (d) Western blots showing the hypothalamic expression of type 4 melanocortin receptor (MC4-R) in female and male F1 mice from the CCD, CRS and NS groups. MC4-R is indicated by the red circle in network C. (e) Quantitative analysis of MC4-R protein expression based on Western blotting. *P < 0.05, **P < 0.01 vs. NS F1 group.

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