Table 3 The regression of cancer incidence on stem cell division and somatic mutation burden.

From: Racial disparities in patient survival and tumor mutation burden, and the association between tumor mutation burden and cancer incidence rate

Model

Explanatory variablea

Adjusted-R2

p-value (SCD)

p-value (DM)

p-value (TSM)

Model-1

SCD, DM

0.374

0.030

0.042

NA

Model-2

SCD, TSM

0.340

0.011

NA

0.079

Model-3

SCD

0.268

0.006

NA

NA

Model-4

DM

0.247

NA

0.008

NA

Model-5

TSM

0.139

NA

NA

0.041

  1. aSCD: the lifetime number of stem cell divisions. DM: the number of somatic mutations in the pan-cancer driver (pcDriver) genes. TSM: the number of somatic mutations present in all HOGO genes. Before the regression analysis, the logarithm transformation is applied to SCD and TSM.
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